ABSTRACT
@#<p style="text-align: justify;">In Malaysia, acromegaly is under-recognised with only 10-15% of the expected number of cases from prevalence estimates, having been diagnosed and managed in established endocrine centres with access to multidisciplinary care. This is mainly due to lack of awareness and standardised approach in diagnosing this disease resulting in delay in diagnosis and management with suboptimal treatment outcomes. This first Malaysian consensus statement on the diagnosis and management of acromegaly addresses these issues and is based on current best practices and latest available evidence so as to reduce the disease burden on acromegaly patients managed in the Malaysian healthcare system.</p>
Subject(s)
Humans , Acromegaly , Consensus , MalaysiaABSTRACT
This study evaluates the growth, body composition, and resistance to Aeromonas hydrophila challenge in juvenile African catfish (Clarias gariepinus) fed diets supplemented with spirulina (Arthrospira platensis). Five experimental diets containing different percentages of locally grown dried spirulina (0, 1, 3, 5 and 7%) were fed daily to catfish juveniles at 5% of their body weight. The growth and body composition of the catfish were determined up to 90 days of the study period. At day 91, the catfish were intraperitoneally injected with 107 CFU/ml of virulent A. hydrophila. Generally, the growth and body composition of the catfish in spirulina inclusion groups showed no significant difference with the control group. The survival rate following A. hydrophila challenge was significantly low in the control group compared to all of the other treatment groups. After the challenge trial, only the white blood cell count value was significantly higher in all of the groups supplemented with spirulina compared to the control group. We concluded that the locally grown spirulina do not improve growth and body composition, but it increased the catfish resistance towards A. hydrophila infection.
ABSTRACT
@#We present a case of a 27-year-old female with T2 DM who developed allergic reactions after commencement of insulin therapy. Trial with different types of insulin resulted in a series of allergic reactions ranging from urticarial rash to development of angioedema, bronchospasm and anaphylactic shock. She was successfully treated with a modified insulin desensitization protocol using rapid-acting insulin.
Subject(s)
ExcipientsABSTRACT
This is a cross-sectional study in a representative sample of preschool children from 12 preschools (TADIKA KEMAS) Pasir Mas, Kelantan, Malaysia. Data on socioeconomic status and sources of water supply at home were collected through interview with mothers. Children’s anthropometric data (height and weight) and body-mass-index-for-age (BMI-for-age) was calculated. Oral examinations of ECC status was based on the dmft index (WHO, 1997). The results showed mean carious teeth were very high (dmft 11.1±4.8) and almost every preschool child was affected with ECC (prevalence 98.1%). The majority were in “high caries” category (i.e. dmft >7) and about 51.4% of preschoolers was underweight and only a few was overweight/obese. Preschool children with high caries mostly were underweight and normal of BMI. The BMI-for-age, household income and household expenditure for food were significant correlation with ECC experience (p<0.05). However, logistic regression showed only family income was a significant factor to ECC.
ABSTRACT
A survey was conducted to assess dental caries experience and oral health related behaviour among Malaysian Territorial Army (TA) personnel. This cross-sectional study involved 284 personnel covering their socio-demography, oral hygiene habits and related behaviour and past utilization of dental services pattern. Dental caries were assessed using DMFT index. Caries prevalence was very high (97.2%; DMFT 8.15±5.36). Untreated decay (DT) was 3.67 (±3.15) and missing teeth (MT) 2.90 (±3.73). However, few were treated teeth (FT) at only 1.58 (±2.02). Almost everyone (98.2%) claimed they brushed their teeth at least once daily and 80% used fluoridated toothpaste. However, very few participants used dental floss (11.3%) while majority (60.2%) did not know about flossing. More than 70% were current smokers. Only 13.7% were regular attendees with the majority (86.3%) visiting the dentist only when they had dental problems. The most common reason (49.7%) for their last dental visit was related to presence of symptoms and few were (27.4%) for prevention. Symptomatic attendees are significantly more likely to have more severe caries experience than preventive oriented individuals (p=0.003). These findings support the importance of promoting preventive oral health utilization behaviour among army personnel.
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The study aimed to investigate acute and sub-acute toxic potential of ethanolic extract of Acacia nilotica [Garad] in rats. LD50 of Garad was determined. Changes in behavioral response, induced by sub-acute treatments were recorded. Elevated urea, creatinine, ALT [GPT] and AST [GOT] in plasma were taken as evidence for impaired kidney and liver function. LD50 of Garad extract was found to be 215.36 mg/kg [124.84-317.47]. Regarding sub acute treatment, observations on seventh and fourteenth days showed slight to moderate sedation at various doses. On day 21 no behavioral changes were recorded. However, a treatment for three weeks induced significant elevation in urea and ALT [p<0.05]. It can be concluded that the ethanolic extract of Garad has got some toxicity when administered sub acutely and intraperitoneally in rats, particularly at high dose [60 mg/kg]
Subject(s)
Male , Animals, Laboratory , Plant Extracts/toxicity , Lethal Dose 50 , Rats , Injections, Intraperitoneal , MiceABSTRACT
Schistosomiasis is the most common problem in Gezira area. The prevalence among school children could reach up to 90% in some villages. This study was conducted in a small village in the Gezira area in central Sudan. This part of the Gezira is well known for its high endemicity of Bilharzia. A total of 428 individuals were included in the study. All were examined clinically and by Ultrasoungraphy for spleen and liver. Stoll specimens were also taken from all the subjects and were examined for Schistosoma mansoni ova. The prevalence of schistosomasis was found to be 72% in males and 68 3% in females. It was also observed that the overall prevalence of splenomegaly on the examined subjects was 35.8%. Males recorded higher prevalence of splenomegaly [38.8%] compared to females [32.7%] [p =/< 0.05]. The observed prevalence of hepatomegaly was 12.6%., with high prevalence among males [13.1%] compared to females [11.2%]. Out of the 406 subjects examined by ultrasound, 266 [63.1%] were found to have evidence of periportal fibrosis. The hepatomegaly in the different grades1.2 and 3 are 12.6%, 3.8% and 0% respectively. It is clear from the above data that the size of the spleen increases while the size of the liver decreases with the severity of periportal fibrosis
Subject(s)
Humans , Male , Female , Schistosomiasis/epidemiology , Schistosomiasis/mortality , Prevalence , Schistosoma mansoni , Ultrasonography , Splenomegaly/pathology , Liver/pathologyABSTRACT
A retrospective analysis was performed on 215 babies to evaluate the incidence of septicemia in babies intubated at birth for aspirating meconium from the trachea. Only term, appropriate for gestational age babies were included. Babies with any known perinatal risk factor for infection were excluded from the study and none of the babies had been put on "prophylactic antibiotics." There were 88 babies in the intubated group in a one year period from January 1991 to December 1991. One hundred and twenty seven babies were taken as controls. There was no significant difference in the incidence of early septicemia in the two groups. There were no deaths in either group. It is concluded that well term babies who are intubated for aspirating meconium need not be put on routine antibiotic cover.